Clinical Trials

Sponsor(s): National Institute of Mental Health (NIMH)

Condition(s):

Eating Disorders
Bulimia nervosa
Binge-eating disorder
Bulimia
Eating Disorder
Binge Eating Disorder

Purpose: This study will determine the effectiveness of the antibiotic erythromycin in enhancing gastrointestinal function and decreasing the frequency of binge eating in people with bulimia nervosa.

Eligibility:

Minimum Age:

18 Years

Maximum Age:

55 Years

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

- Meets DSM-IV criteria for bulimia nervosa

- Duration of illness is greater than 1 year

- Self-induces vomiting

- Weighs 80%-120 % of ideal weight

Exclusion Criteria:

- Significant medical illness

- Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic
disorder, as defined by DSM-IV-TR criteria

- Moderate to severe depression, as defined by a score greater than 18 on the Hamilton
Depression Scales

- Current DSM-IV-TR diagnosis of organic mental disorder, factitious disorder, or
malingering

- History of a personality disorder (e.g., schizotypal, borderline, or antisocial) that
might interfere with assessment or compliance with the study procedures

- At risk for suicide

- Current psychotropic medications and current medications that affect GI function or
that inhibit or induce CYP3A gene expression

- Currently pregnant, lactating, or planning to become pregnant

- Drug or alcohol abuse within the 3 months prior to study entry

- Abnormal EKG at baseline or 1 week following each upward dosage adjustment

- Anemia

- Known intolerance to erythromycin, or related antibiotics

- Abnormal results on liver function tests

- Electrolyte abnormalities

Other Location(s): New York, New York United States

Terms: This is an abstract courtesy of ClinicalTrials.gov, a service of the US National Institute of Health Developed by the National Library of Medicine. ClinicalTrials.gov provides regularly updates information about federally and privately supported clinical research in human volunteers.