Sponsor(s):
National Institute of Mental Health (NIMH)
- Condition(s):
-
Eating Disorders
Anorexia
Anorexia Nervosa
Eating Disorder
Purpose:
This study will compare the concentrations of serotonin transporter in the brains of women
with a history of anorexia nervosa who are currently maintaining a normal weight to those of
healthy women of normal weight.
- Eligibility:
-
- Minimum Age:
- 18 Years
- Maximum Age:
- 45 Years
- Accepts Healthy Volunteers:
- Yes
Inclusion Criteria:
- History of anorexia nervosa
- BMI has been greater than 18.5 kg/m² for at least 9 months
- Agrees to use an effective method of contraception
Exclusion Criteria:
- Use of any psychotropic medication or other types of medications that are likely to
affect the serotonin system within 21 days of study entry
- Current DSM-IV Axis-I diagnosis of any illness other than an eating disorder
- Current AN or history of AN within 9 months prior to study entry
- Presence of any psychiatric symptom that would make participation unsafe
- Significant active physical illnesses, particularly those that may affect the brain
or serotonergic system, including the following: blood dyscrasias lymphomas;
hypersplenism; endocrinopathies; renal failure or chronic obstructive lung disease;
autonomic neuropathies; low hemoglobin; anemia; peripheral vascular disease; and
malignancy
- Currently receiving effective medication treatment for an eating disorder
- History of Raynaud's phenomena and/or acrocyanosis
- Significant regular tobacco use (defined as more than 1 pack per week)
- Lacks capacity to consent
- Pregnant
- Breastfeeding
- Any metal implants, pacemaker, metal prostheses, orthodontic appliances, or the
presence of shrapnel
- Significant history of claustrophobia that would complicate the completion of MRI
- Current or past radiation exposure in the workplace or as part of a research protocol
in the previous year
- Badged for radiation
Other Location(s):
New York, New York United States
Terms:
This is an abstract courtesy of ClinicalTrials.gov,
a service of the US National Institute of Health Developed by the National Library
of Medicine. ClinicalTrials.gov provides regularly updates information about federally
and privately supported clinical research in human volunteers.
