Clinical Trials

Sponsor(s): National Institute of Mental Health (NIMH)

Condition(s):

Eating Disorders
Anorexia
Anorexia Nervosa
Eating Disorder

Purpose: This study will use positron emission tomography imaging to investigate changes in dopamine systems in people with anorexia nervosa before and after weight restoration.

Eligibility:

Minimum Age:

18 Years

Maximum Age:

45 Years

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Participants with AN:

- Meets DSM-IV criteria for AN or ED-NOS (meets criteria for AN except amenorrhea)

- Sufficiently medically and psychiatrically stable to leave inpatient unit, as
assessed by clinical team

Healthy control participants:

- No current or past psychiatric illness

- Between 80% and 120% of ideal body weight

Exclusion Criteria:

All participants:

- Current use of psychotropic medication such as antipsychotics or antidepressants

- Pregnant or breastfeeding

- History of a substance use disorder

- Significant medical illness

- High blood pressure (resting systolic blood pressure greater than 150 mmHg and
diastolic blood pressure greater than 90 mmHg)

- Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic
disorder as defined by DSM-IV-TR

- Metal implants or paramagnetic objects contained within the body that may interfere
with the MRI scan, as determined in consultation with a neuroradiologist and
according to specified reference book guidelines

- Exposed to radiation in the workplace or has had a nuclear medicine procedure during
the 1 year before study entry

- Previous adverse reaction to psychostimulants

Other Location(s): New York, New York United States

Terms: This is an abstract courtesy of ClinicalTrials.gov, a service of the US National Institute of Health Developed by the National Library of Medicine. ClinicalTrials.gov provides regularly updates information about federally and privately supported clinical research in human volunteers.